在1990年4月13日，Banpresto在日本發行Game Boy遊戲《SD魯邦三世 金庫破壞大作戰》(SDルパン三世 金庫破り大作戦 / SD Lupin the 3rd)。這款遊戲忠實呈現動漫原作，主要角色有魯邦三世、次元大輔和石川五右衛門。

遊戲分為5大區域，總共有50個舞台。需要擊敗各個區域的頭目，解救被擄走的女主角峰不二子。在有限的時間內，必須取得鑰匙並打開金庫。沿途會有7種不同的輔助道具，例如，取得無線電對講機就可以獲得次元或五右衛門的協助。而地面上的裝置也有8種。

On April 13, 1990, Banpresto released the Game Boy game "SD Lupin III" (SDルパン三世 金庫破り大作戦 / SD Lupin the 3rd) in Japan. This game faithfully portrays the original anime and features main characters such as Lupin III, Daisuke Jigen, and Goemon Ishikawa.

The game is divided into 5 major regions with a total of 50 stages. Players need to defeat bosses in each region to rescue the kidnapped female lead, Fujiko Mine.

Within a limited time frame, players must obtain keys to unlock the vault. Along the way, there are 7 different types of assisting items, such as obtaining a walkie-talkie to receive assistance from Jigen or Goemon. Additionally, there are 8 types of ground devices.