《瑪利歐醫生》(ドクターマリオ/Dr.Mario)是由任天堂製作和發行的一款與紅白機遊戲，於1990年7月27日移植到Game Boy平台上。同年12月1日，北美版正式上市。遊戲最多有兩人進行競賽，有256K的記憶體。在GBA、3DS和Wii U的Virtual Console上有推出重製版。

需要使用六種不同組合的維生素藥丸來消滅三種不同顏色的病毒，分別是紅色、黃色和藍色。將相同顏色的四個藥丸堆疊在一起，即可清除病毒，需要善用旋轉和位移的操作，類似於俄羅斯方塊的玩法。

將畫面中所有跳動的細菌都去除即可完成關卡，若藥丸堆疊到最上方仍無法消滅病毒則遊戲結束。遊戲共設有20個關卡。從一開始就可選擇關卡、下落速度和音樂等選項。下落速度有慢、中和快三種選擇，音樂則可以選擇代表紅色細菌的Fever、代表藍色細菌的Chill，或者選擇靜音。

在遊戲中，需要利用策略和反應能力來擊敗越來越快速和複雜的關卡。遊戲右上角顯示下一個藥丸的顏色，協助擬定之後的動作。同時，右下角則顯示關卡數和尚未清除的病毒數量，用來了解遊戲進度。

《瑪莉歐醫生》融合解謎、策略和反應元素，為玩家提供一個充滿挑戰和樂趣的遊戲體驗。因其簡單易懂的玩法和吸引人的遊戲性而廣受歡迎，成為任天堂早期遊戲庫中的經典之作。

"Dr. Mario" (ドクターマリオ) is a game developed and published by Nintendo, originally released for the Nintendo Entertainment System (NES) and later ported to the Game Boy platform on July 27, 1990. The North American version was officially launched on December 1 of the same year. The game allows for up to two players to compete and has a memory capacity of 256K. Remakes of the game have been released on the GBA, 3DS, and Wii U's Virtual Console.

Players must use six different combinations of vitamin pills to eliminate three different colors of viruses: red, yellow, and blue. Stacking four pills of the same color together clears the viruses. Players need to make strategic use of rotation and displacement, similar to the gameplay of Tetris.

To complete a level, players must remove all bouncing bacteria from the screen. If the pills stack up to the top without clearing the viruses, the game ends. There are a total of 20 levels in the game. Players can choose options such as level selection, falling speed, and music from the beginning. Speed options include slow, medium, and fast, while music options include "Fever" representing red bacteria, "Chill" representing blue bacteria, or mute.

In the game, players need to utilize strategy and skills to overcome increasingly fast-paced and complex levels. The next pill's color is displayed in the top right corner to help plan the next move. Additionally, the bottom right corner shows the level number and the remaining number of viruses to be cleared, allowing players to track their progress.

"Dr. Mario" combines puzzle-solving, strategy, and reaction elements to provide players with a challenging and enjoyable gaming experience. Its simple and understandable gameplay, along with its engaging gameplay, has made it a classic in Nintendo's early game library.