1991年12月22日由科拿米製作與發行的Game Boy遊戲《大盜五右衛門》（がんばれゴエモン さらわれたエビス丸/ Ganbare Goemon: Sarawareta Ebisumaru!/ Mystical Ninja Starring Goemon）。採用單人進行。記憶體有2M。可透過密碼續關。移植版出現在1997年12月11日的科拿米GB合輯與2012年6月27日的3DS Virtual Console。

這是該系列第一款在GB主機發行的遊戲。故事是從八木十兵衛的手中救出夥伴惠比壽。歐洲的名稱為Mystical Ninja Starring Goemon，關卡的順序則有調整。

舞台相較於紅白機（Famicom）版本更加簡化，並去除時間的限制，也不用拿三張通行證才能通關，畫面上的敵人並不難對付，困難度大幅降低。沒有草鞋也能快速移動。主要武器是近距離攻擊的煙管。取得白貓就能丟出金幣。草鞋能增加速度。該系列的防具如盔甲、斗笠等都可以在商店購買，拉麵可以補充血量。

最多有9個血量。被敵人碰到除會損失1個血量，若擁有草鞋跟射出金幣的功能都會喪失。血歸零的時候就喪失一條生命，落水則直接死亡。第一關是駿河（Suruga）。第二關是和泉（Izumi）。第三關是肥前（Hizen）。第四關是長門（Nagato），頭目是天狗。第五關是石川（Yamashiro），頭目是弁慶。第六關是越後（Echigo），頭目是邪惡官員。第七關是出羽（Dewa），頭目是赤鬼、青二跟萬利休。第八關是陸奧（Michinoku）。第九關是江戶（Edo），頭目是影丸、三人幫跟萬事屋。前三關跟第8關都沒有頭目。

A紐是跳躍。B則是攻擊。保留地道的設定。需要透過跳躍到正確的落點才會出現，可以重複登入大量取得金錢。對藏有金錢的石頭跳一次可以拿到3兩，打到一個敵人可以獲得5兩。透過賭骰子能快速賺取金錢，但風險也很大。

從第2關到第8關有隱藏的珠寶，取得全部後就能看到增加的結局劇情。每次通關就會出現密碼，如果輸入時間過久，五右衛門就會開始打呼。密碼要從7個圖案中挑選4個輸入，圖案有印章、竹筍、丸子、沖天炮、魚丸、壽司、河魨。每關的密碼如下，號碼排列從左上到右下。

第2關1, 3, 2, 4。第3關1, 3, 4, 5。第4關2, 5, 2, 4。第5關2, 5, 4, 5。第6關3, 3, 2, 4。第7關4, 4, 2, 5。第8關4, 6, 4, 4。第9關3, 6, 2, 5。第9關（擁有七個珠寶）4, 6, 3, 7。

當喪失所有生命。出現Continue的畫面時。按上上下下左右右左右BA。這時候就能進入音效測試。

On December 22, 1991, Konami released the Game Boy game "Ganbare Goemon: Sarawareta Ebisumaru!" (がんばれゴエモン さらわれたエビス丸/ Mystical Ninja Starring Goemon). It is a single-player game with a memory size of 2M and features password-based level continuation. The port versions were included in Konami GB compilations on December 11, 1997, and on the 3DS Virtual Console on June 27, 2012.

This was the first game in the series released for the Game Boy console. The story revolves around rescuing the companion Ebisumaru from the hands of Yagi Jubei. In Europe, it was known as "Mystical Ninja Starring Goemon," with some adjustments to the level sequence.

Compared to the Famicom version, the gameplay is more streamlined, with the removal of time limits and the necessity to obtain three passes to complete levels, resulting in significantly reduced difficulty. Enemies on the screen are relatively easy to defeat. Even without the speed shoes, players can move quickly. The primary weapon is a close-range attack pipe. Acquiring a white cat enables the ability to throw coins, while speed shoes increase movement speed. Armor items such as helmets and straw hats can be purchased in shops, and ramen can replenish health.

Players can have a maximum of 9 health points, losing one point when hit by enemies. If equipped with speed shoes or coin-shooting ability, losing all health points will result in their loss. Falling into water leads to immediate death.

The game features various levels: 1. Suruga, 2. Izumi, 3. Hizen, 4. Nagato with Tengu as the boss, 5. Yamashiro with Benkei as the boss, 6. Echigo with evil officials as the boss, 7.Dewa with Akaoni, Aouni, and Manjimaru as bosses, 8. Michinoku, 9.Edo with Kagemaru, the trio, and the Yorozuya as bosses. The first three levels and the eighth level do not have bosses.

Controls include A for jumping and B for attacking. The game maintains the underground passage setting. Players need to jump to the correct landing spots for passages to appear. Player can accumulate large amounts of money by repeatedly entering underground passage. Jumping once on stone containing money yields 3 ryo, and defeating an enemy grants 5 ryo. Money can quickly earn by gambling with dice, but it comes with risks.

Hidden jewels can be found from the second to the eighth levels. Unlocking all of them reveals additional ending scenes. Each level provides a password after completion. If players take too long to enter the password, Goemon starts snoring. Passwords require selecting four symbols from seven options, including stamps, bamboo shoots, dumplings, firecrackers, fish balls, sushi, and pufferfish. Here are the passwords for each level, arranged from top-left to bottom-right:

Level 2: 1, 3, 2, 4 Level 3: 1, 3, 4, 5 Level 4: 2, 5, 2, 4 Level 5: 2, 5, 4, 5 Level 6: 3, 3, 2, 4 Level 7: 4, 4, 2, 5 Level 8: 4, 6, 4, 4 Level 9: 3, 6, 2, 5 Level 9 (with seven jewels): 4, 6, 3, 7

If players lose all their lives and reach the Continue screen, they can enter the Konami code (Up, Up, Down, Down, Left, Right, Right, Left, Right, B, A) to access sound testing.